Important Facts about Sertraline: The Drug of Choice for Bipolar Disorder

Sertraline is a drug categorized as an antidepressant from the family of SSRI or Selective Serotonin Reuptake Inhibitor. This can be prescribed as a treatment of choice for symptoms of depression in bipolar disorders. Antidepressants could contribute to the increase of suicidal behavior and thinking of young adults, adolescents, and even children. Patients who have been initiated with antidepressants must be monitored closely for worsening of symptoms, unusual behavior and suicides. Patients together with their families must seek for help from a psychiatrist immediately, especially when new sets of symptoms appear. Some of the signs that must be watched out for are dangerous or impulsive behavior, thoughts of dying and suicide, restlessness, sleeplessness, hostility and anxiety.

Sertraline are used frequently to stabilize moods, especially when the most usual mood stabilizers are not effective anymore. Mood stabilizers as lithium and lamotrigine are taken concurrently with sertraline in some of the cases.

Drug Interactions

Important Facts about Sertraline: The Drug of Choice for Bipolar Disorder

Antipsychotic drugs, which are usually utilized as mood stabilizers for bipolar disorder treatment, might increase the probability of developing serotonin syndrome if consumed with sertraline. Serotonin syndrome symptoms include vomiting, diarrhea, nausea, weakness, muscle tenseness, impaired coordination, changes in heart rate and blood pressure, agitation, and hallucinations.

Important Facts about Sertraline: The Drug of Choice for Bipolar Disorder


Caution is needed if Sertraline is prescribed to people who have been diagnosed that have bipolar disorder because this might precipitate manic episode. Close symptoms monitoring is needed, especially during the first week of Sertraline bipolar disorder treatment to be able to assess mood changes.

Sertraline must not be prescribed together with MAOIs or Monoamine Oxidase Inhibitors or 14 days right after or just before the treatment with Sertraline. In a few cases, a possibly fatal and serious reaction might occur. Monoamine Oxidase Inhibitors belong to that drug class that utilized for the treatments of Parkinson’s disease, psychiatric conditions, and depression. If you are unsure of whether or not you are prescribed to take a drug belonging to the MAOI class, just do not hesitate to ask the pharmacist about it.

Sertraline might cause the precipitation of life-threatening kind of reactions. Those reactions push the patient’s body to take up a heavy load of serotonin, and the chemical manufactured, and produced the nerve cells. Another potentially fatal reaction is a kind of brain disorder known as neuroleptic syndrome. This will occur when Sertraline is taken with no combination drug or taken with a drug that interacts negatively with it. The symptoms could include changes in mental status, increase in temperature and heart rate, hyperflexia, incoordination, muscle rigidity, diarrhea, vomiting and nausea. When these happen, see a physician immediately.

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